Brain-derived neurotrophic factor also known as BDNF plays a significant role in neuronal survival and development and serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is vital for memory and learning. It's broadly expressed in the CNS, gut, and other cells.
BDNF binds to the high-affinity receptor TrkB or tyrosine kinase B and activates signal transduction cascades, essential for CREB and CBP generation, which encode proteins involved in β cell survival. You can buy a high-quality BDNF ELISA kit from Boster Bio.
Reduced levels of BDNF are related to neurodegenerative disorders with neuronal loss, for example Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Therefore, BDNF might be helpful in the prevention and control of many diseases like diabetes mellitus. Individual BDNF quantitates human BDNF in serum, plasmascreen, supernatant.
The BDNF ELISA assay will only recognize both natural and recombinant human BDNF. BDNF is a part of the neurotrophin family. BDNF is broadly expressed in the central nervous system also functions in an autocrine and paracrine manner on many types of neurons.
BDNF is triggered by cortical neurons, and is vital for survival of striatal neurons within the mind. Expression of BDNF is decreased in Alzheimer's and Huntington disease sufferers, and might also play a part in the regulation of stress response and at the research of mood disorders. Brain-derived neurotrophic factor (BDNF) is among the neurotrophic factors which encourage differentiation, maturation and survival of neurons in the nervous system.